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Abstract #1978

Dynamic Sliding-Window MRS Method for Measuring Changes in Glutamate and GABA in Patients with Major Depressive Disorder

John Port1, Balwinder Singh2, and Mark A Frye2
1Mayo Clinic, Rochester, MN, United States, 2Department of Psychiatry, Mayo Clinic, Rochester, MN, United States

We have developed a method of optimally frequency/phase adjusting individual FIDS of an MRS acquisition such that patient motion and scanner artifacts can be eliminated from long MRS acquisitions. This method uses MRS peak symmetry in order to optimally phase the Cho and Cr peaks acquired using a frequency-locked MEGA-PRESS sequence. We tested our method subjects receiving an IV ketamine infusion for MDD and noticed dramatic changes in GABA and Glx levels in one subject. Our method allows for dynamic MRS studies that can measure neurotransmitter changes over time.

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