Abstract #1977

Increased Connectivity Correlated to Severity of Autism in a Cohort of High Functioning Autism and Major Depressive Disorder

Mario Serrano-Sosa¹, Chuan Huang^1,2,3, Christine DeLorenzo^1,2, and Kenneth Gadow²

¹Biomedical Engineering, Stony Brook University, Stony Brook, NY, United States, ²Psychiatry, Stony Brook University, Stony Brook, NY, United States, ³Radiology, Stony Brook University, Stony Brook, NY, United States

This is the first study to investigate connectivity in a cohort of High Functioning Autism (HFA) and Major Depressive Disorder (MDD) subjects with comorbid autism. Using DSI studio for connectometry analysis, we investigated the relationship between Social Responsiveness Scale (SRS) scores and Spin Distribution Function (SDF) values derived from diffusion MRI images. Tractography based analysis showed corpus callosum, longitudinal fasciculus and corticothalamic pathways to have increased connectivity relating to SRS scores (FDR=0.011). Post hoc analysis showed trend-level partial correlation between SRS and SDF while controlling for IQ scores (p=0.056, r=0.480).

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