Neuromodulatory interventions have shown promise in the treatment of Obsessive-Compulsive Disorder (OCD). However, the nature of the aberrants circuits that cause the disease as well as the network changes that are the basis of improvement following treatment are not well understood. Here we analyzed OCD patients treated with either MRI-guided focused ultrasound capsulotomy or deep brain stimulation targeting the inferior thalamic peduncle. Using neuroimaging analysis and modeling techniques we found that a fronto-limbic network (DLPFC, dorsal ACC, and amygdala) predicts individual improvement across groups. These results provide new insight into OCD and how to possibly refine neuromodulatory therapies.