Abstract #1986

Disrupted Resting-State Functional Connectivity of Amygdala Subregions in Obsessive-Compulsive Disorder

Lingxiao Cao¹, Hailong Li¹, Xinyu Hu¹, Jing Liu¹, Yingxue Gao¹, Xuan Bu¹, Lianqing Zhang¹, Lu Lu¹, Shi Tang¹, Yanlin Wang¹, Xinyue Hu¹, Qiyong Gong¹, and Xiaoqi Huang¹

¹Huaxi MR Research Center (HMRRC), Functional and molecular imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu, China

Using seed based FC analysis, we investigated alterations in functional connectivity of amygdala subregions in OCD. Our findings (ⅰ) indicated OCD patients, relative to HC, have anomalous amygdala resting state network connections to brain regions that play a pivotal role in emotional processing; (ⅱ) identified CM/Astr-PCG hyperconnectivity and CM-cuneus hyperconnectivity, which were not detected when using the whole amygdala as a seed; (ⅲ) demonstrated FC measures of significant regions were correlated with illness duration and symptom severity. Besides, we found that functional aberrations were accompanied with anatomical changes in OCD. These findings may contribute to revealing the pathophysiology underlying OCD.

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