Abstract #1987

Disorder-specific alternations of intrinsic brain functional network dynamics in obsessive-compulsive disorder and schizophrenia

Fei Li^1,2, Lekai Luo^1,2, Qian Li^1,2, Wanfang You^1,2, and Qiyong Gong^1,2

¹Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, ²Psychoradiology Research Unit of Chinese Academy of Medical Sciences (2018RU011), West China Hospital of Sichuan University, Chengdu, China

Dynamic functional connectivity (dFC) analyses were used to compare the intrinsic brain functional network dynamics in patients with obsessive-compulsive disorder (OCD) and schizophrenia (SZ), by using resting-state functional MRI (rfMRI). We found that patients with OCD and SZ showed distinct disorder-specific alternations of brain dynamics and the higher fractional time in state 2 may indicate the more anxiety ratings in OCD patients.

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