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Abstract #1988

dACC Dysfunction During Inhibitory But Not Excitatory Motor Control in OCD: Glutamate Dysmodulation Estimated using ¹H fMRS

Jeffrey A. Stanley1, Asadur Chowdury2, Dalal Khatib2, Phillip Easter2, David R. Rosenberg2, and Vaibhav A. Diwadkar2
1Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, United States, 2Wayne State University School of Medicine, Detroit, MI, United States

Loss of the E/I balance of the dACC in OCD was assessed using a combination of a) motor control tasks with distinct excitatory and inhibitory modes of responding, and b) ¹H fMRS to quantify evoked glutamate changes. Basal (task-independent) glutamate levels were comparable to healthy controls, as were levels during excitatory modes of responding. However, the inhibitory mode of responding induced a specific deficit in the degree of dACC glutamate modulation in OCD patients. In surmounting shortcomings of fMRI, ¹H fMRS successfully identified loss of excitation in the E/I balance of the dACC during specific phases of motor control.

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