Loss of the E/I balance of the dACC in OCD was assessed using a combination of a) motor control tasks with distinct excitatory and inhibitory modes of responding, and b) ¹H fMRS to quantify evoked glutamate changes. Basal (task-independent) glutamate levels were comparable to healthy controls, as were levels during excitatory modes of responding. However, the inhibitory mode of responding induced a specific deficit in the degree of dACC glutamate modulation in OCD patients. In surmounting shortcomings of fMRI, ¹H fMRS successfully identified loss of excitation in the E/I balance of the dACC during specific phases of motor control.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords