Abstract #1989

Temporal variability of local brain activity in medication-free patients with Obsessive Compulsive Disorder

Jing Liu¹, Yingxue Gao¹, Hailong Li¹, Xuan Bu¹, Lingxiao Cao¹, Lianqing Zhang¹, Suming Zhang¹, Xinyu Hu¹, and Xiaoqi Huang¹

¹Huaxi MR Research Center (HMRRC), Functional and molecular imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China, Chengdu, China

In current study, we use static and dynamic amplitude of low-frequency fluctuation / fractional low-frequency fluctuation (ALFF/fALFF) to assess the local brain activity on patients with obsessive-compulsive disorder (OCD). We found that both static and dynamic ALFF/fALFF can detect certain cerebral region with abnormal activity, however, dynamic ALFF/fALFF can demonstrate additional brain regions that are ignored by static ALFF/fALFF. In addition, we found that there is significant correlation between cerebellum activity and clinical scale, which suggested the crucial role of cerebellum in the pathophysiology of OCD.

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