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Abstract #1990

Dynamic characteristics of functional connectivity in the first-episode and treatment-naive patients with obsessive-compulsive disorder

Junhong Liu1, Xiaoming Li1, Kaiyu Wang2, and Jingliang Cheng1
1The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China, 2GE Healthcare, MR Research China, Beijing, China

Compared with task-activation studies, dynamics are potentially even more prominent during resting-state, when mental activity is unconstrained. To assess whole-brain dynamic functional connectivity of first-episode and treatment-naive patients with obsessive-compulsive disorder (OCD), we used a series of methods including independent component analysis, sliding windows and k-means clustering. Our results indicated that OCD groups displayed more transitions between different states than healthy controls. This change was positively correlated with clinical scale scores, potentially contributing to better understanding of the dynamic neural mechanism of OCD.

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