Abstract #1993

Common and distinct patterns of intrinsic brain activity alterations in major depression and bipolar disorder: voxel-based meta-analysis

JiaYing Gong^1,2, Junjing Wang³, Shaojuan Qiu¹, Long Qian⁴, Li Huang¹, and Ying Wang¹

¹Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China, ²Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ³Department of Applied Psychology, Guangdong University of Foreign Studies, Guangzhou, China, ⁴MR Research, GE Healthcare, Beijing, China

This is the largest voxel-based meta-analysis conducted to date of amplitude of low-frequency fluctuation (ALFF) studies in major depressive disorder (MDD) and bipolar disorder (BD). MDD and BD show a common pattern of aberrant regional intrinsic brain activity which predominantly includes the insula, medial prefrontal cortex (mPFC), and cerebellum. These results expand on a growing literature exploring resting-state activity in MDD and BD, which provide useful insights for understanding the underlying pathophysiology of brain dysfunction in affective disorders, and developing more targeted and efficacious treatment and intervention strategies.

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