Smaller hippocampus is a consistent finding in studies of major depressive disorder (MDD), and subfield-level anatomic analyses could provide new insights to the role of hippocampal deficit in MDD. In the current study, we recruited a relatively large sample of MDD patients and demonstrated that (1) “core structures” including CA and dentate gyrus are more anatomically involved in MDD than other structures in hippocampus; (2) hippocampal tail might be important in MDD, but the relationship between hippocampal tail and MDD could be complex; (3) smaller hippocampus could contribute to memory deficit in MDD patients by failure in long-term memory formation.
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