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Abstract #1994

Smaller Hippocampal Subfields Associate with Poorer Logical Memory Performance in a Large Sample of MDD Patients

Lianqing Zhang1, Xinyu Hu1, Lu Lu1, Xuan Bu1, Yingxue Gao1, Shi Tang1, Kaili Liang1, Lingxiao Cao1, Yanlin Wang1, Xinyue Hu1, Jing Liu1, Qiyong Gong1, and Xiaoqi Huang1
1Radiology, Huaxi MR Research Center (HMRRC), Sichuan University, Chengdu, China

Smaller hippocampus is a consistent finding in studies of major depressive disorder (MDD), and subfield-level anatomic analyses could provide new insights to the role of hippocampal deficit in MDD. In the current study, we recruited a relatively large sample of MDD patients and demonstrated that (1) “core structures” including CA and dentate gyrus are more anatomically involved in MDD than other structures in hippocampus; (2) hippocampal tail might be important in MDD, but the relationship between hippocampal tail and MDD could be complex; (3) smaller hippocampus could contribute to memory deficit in MDD patients by failure in long-term memory formation.

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