To better understand the underlying mechanisms for emotional disturbances in patients with major depressive disorder (MDD), we used structural brain connectivity analysis to investigate the differences in global and local network organization of MDD and healthy controls. Our results demonstrated that both global and local efficiency of patients with MDD were significantly decreased due to depressive symptoms, and that higher depression severity, anxiety somatization and cognitive disturbance were significantly associated with decreased network efficiency. These results indicated that brain network analysis is a useful tool to link psychological disorders with their underlying anatomical substrate.
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