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Abstract #1995

Altered network efficiency is associated with mood disturbance in adults with major depressive disorder

Xiaopei Xu1 and Lanying Liu2
1Department of Radiology, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China, 2Department of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou, China

To better understand the underlying mechanisms for emotional disturbances in patients with major depressive disorder (MDD), we used structural brain connectivity analysis to investigate the differences in global and local network organization of MDD and healthy controls. Our results demonstrated that both global and local efficiency of patients with MDD were significantly decreased due to depressive symptoms, and that higher depression severity, anxiety somatization and cognitive disturbance were significantly associated with decreased network efficiency. These results indicated that brain network analysis is a useful tool to link psychological disorders with their underlying anatomical substrate.

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