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Abstract #1996

Glutamatergic involvement of left DLPFC and left anterior insula in treatment resistant major depressive disorder

Pallab K Bhattacharyya1,2, Murat Altinay3, Xuemei Huang1, Jian Lin1, Mark Lowe1, and Amit Anand3
1Imaging Institute, Cleveland Clinic, Cleveland, OH, United States, 2Radiology, Cleveland Clinic Lerner College of Medicine, CLEVELAND, OH, United States, 3Neurogolical Institute, Cleveland Clinic, Cleveland, OH, United States

Six subjects with treatment resistant major depressive disorder (MDD) were scanned with resting state functional connectivity (rsfMRI)and GABA/Glx editing protocol. rsFMRI between left dorsolateral prefrontal cortex (lDLPFC) and left anterior insula (lAI), two nodes of physiological importance in MDD, inversely correlated with Glx at DLPFC. No such association was observed between rsfMRI and GABA. lDLPFC-lAI rsfMRI, lDLPFC GABA or Glx levels did not correlate with disease severity. The results suggest a collective role of lDLPFC and lAI in MDD via a glutamatergic mechanism.

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