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Abstract #1997

Ketamine modulation of Cerebro-Cerebellar Circuitry During Response Inhibition in Major Depression

Joana R. A. Loureiro1, Ashish K. Sahib1, Megha Vasavada1, Antoni Kubicki1, Shantanu Joshi1, Benjamin Wade1, Amber Leaver2, Roger Woods1, Randall Espinoza3, and Katherine Narr1
1Neurology, Ahamason-Lovelace Brain Mapping Center, UCLA, Los Angeles, CA, United States, 2Radiology, Center for Translational Imaging, Northwestern University, Chicago, IL, United States, 3Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA, United States

Treatments for major depressive disorder (MDD) target communication between large-scale cortical networks and the cerebellum to improve cognitive control [2]. Here, we examined how repeated-ketamine perturbs cerebro-cerebellar circuitry during response-inhibition using a NoGo/Go task (43 MDD-patients receiving ketamine, 31 controls). We implemented a psychophysiological-interaction analysis to investigate ketamine-related changes in connectivity between cerebellum-regions and cortical-networks and respective nodes. Results showed significant decreases in connectivity between a cerebellum-dorsal-attention region and the default-network. A time-by-response interaction for the somatomotor-network was observed in treatment-responders only. Results support ketamine modulates cerebello-cerebro circuitry, which may be of impact for identifying new biomarkers of MDD response.

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