Abstract #2003

The impact of B1+ inhomogeneities on automatic hippocampal morphometry using 7T MRI

Roy AM Haast¹, Jonathan C Lau^1,2, Dimo Ivanov³, Kamil Uludag^4,5, and Ali R Khan^1,6

¹Robarts Research Institute, Western University, London, ON, Canada, ²Department of Clinical Neurological Sciences, Division of Neurosurgery, Western University, London, ON, Canada, ³Department of Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands, ⁴Institute for Basic Science, Center for Neuroscience Imaging Research, Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea, ⁵University Health Network, Toronto, ON, Canada, ⁶Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada

We examined the effect of B₁⁺ inhomogeneities in 7T MP2RAGE data on hippocampal morphometry using volume- and surface-based evaluation methods. As for the cortex, significant variability in hippocampal and subcortical segmentation outputs are observed between original and corrected MP2RAGE data, especially near GM-CSF boundaries. Importantly, results of data acquired at two sites, using different MR hardware and sequence setups (B₁⁺-sensitive vs insensitive), become more comparable after B₁⁺ correction. These data emphasize the dependency of segmentation performances on anatomical image quality, and stresses the need for careful consideration of sequence parameters when setting up imaging protocols.

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