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Abstract #2003

The impact of B1+ inhomogeneities on automatic hippocampal morphometry using 7T MRI

Roy AM Haast1, Jonathan C Lau1,2, Dimo Ivanov3, Kamil Uludag4,5, and Ali R Khan1,6
1Robarts Research Institute, Western University, London, ON, Canada, 2Department of Clinical Neurological Sciences, Division of Neurosurgery, Western University, London, ON, Canada, 3Department of Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands, 4Institute for Basic Science, Center for Neuroscience Imaging Research, Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea, 5University Health Network, Toronto, ON, Canada, 6Department of Medical Biophysics, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada

We examined the effect of B1+ inhomogeneities in 7T MP2RAGE data on hippocampal morphometry using volume- and surface-based evaluation methods. As for the cortex, significant variability in hippocampal and subcortical segmentation outputs are observed between original and corrected MP2RAGE data, especially near GM-CSF boundaries. Importantly, results of data acquired at two sites, using different MR hardware and sequence setups (B1+-sensitive vs insensitive), become more comparable after B1+ correction. These data emphasize the dependency of segmentation performances on anatomical image quality, and stresses the need for careful consideration of sequence parameters when setting up imaging protocols.

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