This abstract describes a novel dynamic T2-relaxation contrast magnetic resonance imaging (DRC-MRI) protocol for mapping the cerebral perfusion dynamics in mice. We demonstrate how to quantify cerebral perfusion dynamics with the proposed DRC modeling, which combines features of both dynamic and the steady-state methods. Quantitative analysis on both simulated and in vivo experimental data are performed. We first validate the reliability of our DRC modeling protocol with healthy mice before we apply the protocol on a tumor treatment study. We are able to demonstrate its ability to model the treatment effect of Etoposide on Glioblastoma in mice.