High Intensity Focused Ultrasound (HIFU) in now entering clinical practice, for example to treat essential tremor by causing small lesions in the thalamus. Due to small size of treatment lesions, treatment success depends critically on targeting, which is classically done using measurments and landmarks. We explore an alternative method using functional imaging to guide targeting, specifically using 7T resting state connectivity. We present preliminary data of the patterns of connectivity possible with 7T using a concatenated series of healthy subjects. Finally, we show the changes in connectivity in a post-HIFU patient from the thalamus to the cortex.