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Abstract #2009

Dynamic response profiling of periaqueductal grey during a bladder filling protocol using 7T functional MRI

Job van den Hurk1,2, Mathijs de Rijk3, Sajjad M Rahnama'i3, and Gommert van Koeveringe4
1Scannexus Ultra-High Field MRI Center, Maastricht, Netherlands, 2Department of Cognitive Neuroscience, Maastricht University, Maastricht, Netherlands, 3Department of Urology, Maastricht University, Maastricht, Netherlands, 4Department of Urology, Maastricht University Medical Center (MUMC+), Maastricht, Netherlands

The periaqueductal grey (PAG) is a brainstem nucleus involved in storage and voiding of urine. We developed a novel method for creating dynamic response profiles for PAG, which requires three resting state ultra-high resolution fMRI datasets to be acquired: the first when the participant has an empty bladder, the second during filling of the bladder while subjective bladder sensations are recorded, and the third with a full bladder. PAG is functionally parcellated based on the full bladder scan, after which functional connectivity between the clusters is assessed for different states of bladder sensation.

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