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Abstract #2011

An MRI traumatic brain injury case study at 7 Tesla: pre- and post-injury structural network and volumetric reorganization and recovery

Stephanie S. G. Brown1,2, Kristen Dams-O'Connor3, Priti Balchandani4, and Rebecca E. Feldman5
1Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom, 2Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai / University of Cambridge, New York, NY, United States, 3Brain Injury Research Centre, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 4Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 5Department of Computer Science, Mathematics, Physics, and Statistics, University of British Columbia, Kelowna, BC, Canada

This case study investigates the structural effects of traumatic brain injury for the first time using pre-injury and post-injury 7 Tesla MRI longitudinal data. We report findings of initial volumetric changes, decreased structural connectivity and reduced microstructural order that appear to return to baseline 8 months post-injury, suggestive of long-term plasticity and recovery.

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