Abstract #2011

An MRI traumatic brain injury case study at 7 Tesla: pre- and post-injury structural network and volumetric reorganization and recovery

Stephanie S. G. Brown^1,2, Kristen Dams-O'Connor³, Priti Balchandani⁴, and Rebecca E. Feldman⁵

¹Department of Psychiatry, University of Cambridge, Cambridge, United Kingdom, ²Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai / University of Cambridge, New York, NY, United States, ³Brain Injury Research Centre, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁴Biomedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁵Department of Computer Science, Mathematics, Physics, and Statistics, University of British Columbia, Kelowna, BC, Canada

This case study investigates the structural effects of traumatic brain injury for the first time using pre-injury and post-injury 7 Tesla MRI longitudinal data. We report findings of initial volumetric changes, decreased structural connectivity and reduced microstructural order that appear to return to baseline 8 months post-injury, suggestive of long-term plasticity and recovery.

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