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Abstract #2012

Altered visual pathway dynamics upon dark rearing of mice captured with ultra-fast fMRI

Rita Gil1 and Noam Shemesh1
1Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal

Dark rearing (DR) profoundly affects visual processing. Decreased flash responsiveness and increased off-response latencies were reported in DR mice visual cortex (VC). Here, we targeted such plastic changes in activation dynamics using ultrafast fMRI upon mice monocular visual stimulation. Our results, targeting the most of the pathway, showed decreased BOLD amplitudes in most visual pathway structures as well as less well-defined neuronal input order. Activation maps revealed marked increases in ipsilateral response in DR mice compared to controls. These results reveal that BOLD fMRI can depict visual pathway plasticity, and suggests a naïve and unskilled network upon DR.

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