Our goal is to propose a new approach to construct the brain anatomical connectivity networks using T1 mapping, and verify whether this novel brain network has higher Small-Worldness and efficiency organization. We reviewed the previous studies, and discovered that the cortical layers could be delineated on the basis of myeloarchitecture, while T1 mapping strongly correlated with intro-cortical myelin contents. Hence, it is feasible to quantify the anatomical connectivity using T1 mapping. Our resulted supported our hypothesis and highlighted the higher Small-Worldness and efficiency of this network compared with conventional macroscale cortical morphometry based approach.
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