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Abstract #2025

Troponin T is a potential indicator for nerve damage in Type 2 Diabetes - results from Diffusion Tensor Imaging of the sciatic nerve

Johann Malte Enno Jende1, Stefan Kopf2, Zoltan Kender2, Artur Hahn1, Jakob Morgenstern3, Peter Paul Nawroth2, Martin Bendszus1, and Felix Tobias Kurz1
1Neuroradiology, Heidelberg University Hospital, Heidelberg, Germany, 2Internal Medicine I / Endocrinology, Heidelberg University Hospital, Heidelberg, Germany, 3Laboratory medicine, Heidelberg University Hospital, Heidelberg, Germany

Diabetic neuropathy (DN) is one of the most severe complications of Diabetes mellitus. This study sought to investigate potential correlations between high sensitivity Troponin T (hsTNT) assays and peripheral nerve fractional anisotropy (FA) in diffusion tensor imaging (DTI) in 51 patients with diabetes. We found negative correlations of hsTNT with the sciatic nerve's FA (r=-0.52;p<0.001) and sural, tibial, and peroneal nerve conduction velocities (0.65,p<0.001; r=-0.44,p=0.002, and r=-0.42,p=0.003, respectively). Our results indicate that hsTNT is a potential marker for microangiopathy-related nerve damage in diabetic neuropathy.

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