Abstract #2035

Chronic effects of smoking on the brain oxygenation and perfusion using ASL and quantitative BOLD MRI

Sebastian Thomas¹, Simon Hubertus¹, Alycia Lee², Sabine Vollstädt-Klein*², and Lothar R. Schad*¹

¹Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ²Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

The effects of smoking on human brain hemodynamics have been investigated in PET studies, but no real consensus has been found. In this study, an MRI-based approach using arterial spin labelling and multi-parametric quantitative BOLD is implemented to measure the chronic effects of cigarette smoking on the cerebral blood flow, oxygen extraction fraction and cerebral metabolic rate of oxygen. Chronic effects between smokers and never-smokers were detected in three regions for CBF, three regions for OEF, and one region for CMRO2.

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