The purpose was to evaluate the differential degree of iron deposition in deep gray-matter regions in a healthy population of cigarette smokers (n=8) and non-smokers (n=7) using quantitative susceptibility mapping (QSM). All subjects underwent anatomical imaging and 3D-susceptibiluty weighted imaging on a 7T MR system. A trend towards higher QSM was observed in smokers than in non-smokers from globus pallidus region. All other DGM regions also had higher QSM values in smokers compared to those of non-smokers, however, no significant differences were observed. Future studies are warranted to validate our findings in a larger cohort.