Abstract #2036

Quantitative Susceptibility Mapping in a Healthy Population of Cigarette Smokers

Sanjeev Chawla¹, Emily Devlin², Claudia Ianelli³, Deepa Thakuri¹, Dushyant Kumar¹, Hari Hariharan¹, Suyash Mohan¹, James Loughead², Cynthia Neill Epperson³, Ravinder Reddy¹, and Ravi Prakash Reddy Nanga¹

¹Department of Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, ²Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States, ³University of Clorado School of Medicine, Aurora, CO, United States

The purpose was to evaluate the differential degree of iron deposition in deep gray-matter regions in a healthy population of cigarette smokers (n=8) and non-smokers (n=7) using quantitative susceptibility mapping (QSM). All subjects underwent anatomical imaging and 3D-susceptibiluty weighted imaging on a 7T MR system. A trend towards higher QSM was observed in smokers than in non-smokers from globus pallidus region. All other DGM regions also had higher QSM values in smokers compared to those of non-smokers, however, no significant differences were observed. Future studies are warranted to validate our findings in a larger cohort.

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