Abstract #2037

Effect of memory retrieval-extinction procedure on the brain of patients in smoking cessation revealed by resting-state fMRI

Shih-Yu Huang¹, Ming-Chou Ho^2,3, and Jun-Cheng Weng^1,4,5

¹Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan, ²Department of Psychology, Chung Shan Medical University, Taichung, Taiwan, ³Clinical Psychological Room, Chung Shan Medical University Hospital, Taichung, Taiwan, ⁴Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, ⁵Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan

Previous studies used memory retrieval-extinction procedure to successfully reduce the drug self-administration behavior in rats and heroin patients. The method was rarely used in smoking cessation. This study used resting-state fMRI to evaluate the effect of memory retrieval-extinction procedure on heavy smokers. We found that lower default mode network activity and higher reward system activation in smokers who finished the memory retrieval-extinction procedure. It may reflect a nonpharmacological method induced the smoking-related emotions but reduced smoking memory retrieval. In conclusion, our results could give a new perspective on clinical treatment for smoking cessation.

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