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Abstract #2037

Effect of memory retrieval-extinction procedure on the brain of patients in smoking cessation revealed by resting-state fMRI

Shih-Yu Huang1, Ming-Chou Ho2,3, and Jun-Cheng Weng1,4,5
1Department of Medical Imaging and Radiological Sciences, Chang Gung University, Taoyuan, Taiwan, 2Department of Psychology, Chung Shan Medical University, Taichung, Taiwan, 3Clinical Psychological Room, Chung Shan Medical University Hospital, Taichung, Taiwan, 4Medical Imaging Research Center, Institute for Radiological Research, Chang Gung University and Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan, 5Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan

Previous studies used memory retrieval-extinction procedure to successfully reduce the drug self-administration behavior in rats and heroin patients. The method was rarely used in smoking cessation. This study used resting-state fMRI to evaluate the effect of memory retrieval-extinction procedure on heavy smokers. We found that lower default mode network activity and higher reward system activation in smokers who finished the memory retrieval-extinction procedure. It may reflect a nonpharmacological method induced the smoking-related emotions but reduced smoking memory retrieval. In conclusion, our results could give a new perspective on clinical treatment for smoking cessation.

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