Diffusion
tensor imaging (DTI), relaxation time, and magnetization ratio (MTR)-based studies
have shown that obesity negatively impacts microstructural white matter (WM) integrity.
However, the specific impact of obesity on myelin content has not previously
been evaluated. Here, we examined the relationship between obesity status,
measured using body mass index (BMI), and myelin content, measured using myelin
water fraction (MWF) mapping, a surrogate of myelin content, in a large age
cohort of cognitively unimpaired lean, overweight, and obese subjects. Our
results indicate that BMI is negatively associated with MWF in several brain WM
regions.
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