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Abstract #2038

Association of decreased cerebral myelination with obesity

Mustapha Bouhrara1, Nikkita Khattar1, Luis E. Cortina1, Abinand C. Rejimon1, Elango Palchamy1, Susan M. Resnick1, and Richard G. Spencer1
1NIA, NIH, Baltimore, MD, United States

Diffusion tensor imaging (DTI), relaxation time, and magnetization ratio (MTR)-based studies have shown that obesity negatively impacts microstructural white matter (WM) integrity. However, the specific impact of obesity on myelin content has not previously been evaluated. Here, we examined the relationship between obesity status, measured using body mass index (BMI), and myelin content, measured using myelin water fraction (MWF) mapping, a surrogate of myelin content, in a large age cohort of cognitively unimpaired lean, overweight, and obese subjects. Our results indicate that BMI is negatively associated with MWF in several brain WM regions.

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