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Abstract #2040

Hippocampal and Systemic Oxidative Stress in a rat model of Chronic Hepatic Encephalopathy, a multimodal approach

Katarzyna Pierzchala1, Dunja Simicic1, Andrzej Sienkiewicz2, Dario Sessa3, Stefanita Mitrea4, Olivier Braissant5, Valerie McLin3, Rolf Gruetter1, and Cristina Cudalbu4
1CIBM / LIFMET / EPFL, Lausanne, Switzerland, 2LPMC / EPFL, Lausanne, Switzerland, 3Center for Liver Disease in Children,Department of Paediatrics, HUG, Geneva, Switzerland, 4CIBM / EPFL, Lausanne, Switzerland, 5Service of Clinical Chemistry, CHUV, Lausanne, Switzerland

Chronic hepatic encephalopathy (CHE) is a multifactorial disease. The presence of central nervous system (CNS) and systemic oxidative stress (OS) is thought to contribute to the pathogenesis of CHE. Clinically, it is known that peripheral inflammation contributes to acute worsening of patients with CHE. We used in-vivo 1H-MRS, ex-vivo/in-vitro ESR and histology of CNS to investigate longitudinally the course of OS in the rat model of CHE. Our studies revealed antioxidant system impairment (decrease of CNS Asc and GSH, post-BDL) and increased CNS and systemic OS over the course of CHE progression, concomitant with CNS Gln and systemic NH4+ increase.

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