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Abstract #2042

Kinetics of O-17-labeled water in the brain parenchyma and cerebrospinal fluid of aquaporin-4-knockout mice on indirect MRI

Yutaka Hoshino1, Hiroyuki Kameda1, Taisuke Harada1, Yuji Komaki2, Tomoe Ishikawa3, Masato Yasui3, and Kohsuke Kudo1
1Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan, 2Live Imaging Center, Central Institute for Experimental Animals, Kawasaki, Japan, 3Department of Pharmacology, Keio University School of Medicine, Tokyo, Japan

We evaluated the water kinetics of the brain of intoxication model mice to compare aquaporin-4-knockout (AQP4-KO) and wild-type (WT) control mice, using T2-weighted indirect MRI with 17O-labeled water. Eleven AQP4-KO and eight WT mice were scanned with 7T MRI using the RARE sequence. 17O-labeled water was administered intraperitoneally. The whole scanning took 540 phases and 45 min, and signals were converted to 17O concentrations. In ROIs of the brain parenchyma, steady-state 17O concentrations were slightly higher in AQP4-KO than in WT. The latest imaging method revealed that the deficiency of AQP4 might lead to water accumulation in the paravascular space.

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