We evaluated the water kinetics of the brain of intoxication model mice to
compare aquaporin-4-knockout (AQP4-KO) and wild-type (WT) control mice, using
T2-weighted indirect MRI with 17O-labeled water. Eleven AQP4-KO and
eight WT mice were scanned with 7T MRI using the RARE sequence. 17O-labeled
water was administered intraperitoneally. The whole scanning took 540 phases
and 45 min, and signals were converted to 17O concentrations. In ROIs
of the brain parenchyma, steady-state 17O concentrations were
slightly higher in AQP4-KO than in WT. The latest imaging method revealed that the
deficiency of AQP4 might lead to water accumulation in the paravascular space.
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