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Abstract #2055

Reproducibility of diffusion tensor imaging (DTI) on 12 clinical scanners: Towards validation of cardiac DTI sequences.

Irvin Teh1, William Romero2, Erica Dall'Armellina1, Daniel Ennis3, Pedro F. Ferreira4, Prateek Kalra5, Arunark Kolipaka5, Sebastian Kozerke6, David Lohr7, Kevin Moulin8, Christopher Nguyen9, Sonia Nielles-Vallespin4, Beau Pontre10, Laura M. Schreiber7, Andrew Scott4, David Sosnovik9, Christian T. Stoeck6, Cyril Tous11, Elizabeth Tunnicliffe12, Vicky Wang13, Andreas M. Weng14, Alistair Young15, Pierre Croisille2, Magalie Viallon2, and Jürgen E. Schneider1
1Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom, 2Université de Lyon, UJM-Saint-Etienne, INSA, CNRS UMR 5520, INSERM U1206, CREATIS, F-42023, Saint Etienne, France, 3Department of Radiology, VA Palo Alto Health Care System, Palo Alto, CA, United States, 4Royal Brompton Hospital and Imperial College, London, United Kingdom, 5Department of Radiology, The Ohio State University Wexner Medical Center, Columbus, OH, United States, 6Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 7Department of Cardiovascular Imaging, Comprehensive Heart Failure Center, Würzburg, Germany, 8Stanford University, Stanford, CA, United States, 9Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States, 10Department of Anatomy and Medical Imaging, The University of Auckland, Auckland, New Zealand, 11Department of Radiology, Radiation-Oncology and Nuclear Medicine and Institute of Biomedical Engineering, Université de Montréal, Montréal, QC, Canada, 12University of Oxford, Oxford, United Kingdom, 13San Francisco Veteran Affairs Medical Center, San Francisco, CA, United States, 14Department of Diagnostic and Interventional Radiology, University Hospital Würzburg, Würzburg, Germany, 15Department of Biomedical Engineering, King's College London, London, United Kingdom

Cardiac diffusion tensor imaging (DTI) is increasingly used for non-invasive in vivo characterisation of cardiac microstructure. To help reconcile the variation in DTI metrics in the literature, we investigated the inter- and intra-site variation of DTI across twelve clinical scanners. Data were acquired at two time points, with a standardised isotropic phantom, acquisition, and post-processing pipeline. In water at 0°C, the coefficient of variation of mean diffusivity (MD) across sites was 1.9 ± 1.4% (mean ± SD), while the mean difference across two scans was (-0.010 ± 0.098) × 10-3 mm2/s (mean ± 1.96SD), indicating low bias and good reproducibility.

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