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Abstract #2069

Multiphase CINE T2*-mapping of the mouse heart at 9.4 tesla

Sandra Lehmann1,2, Min-Chi Ku1,3, Joao dos Santos Periquito1, Han Haopeng1, Andreas Pohlmann1, and Thoralf Niendorf1,3,4
1Berlin Ultrahigh Field Facility (B.U.F.F.), Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany, 2Technische Universität Berlin, Berlin, Germany, 3DZHK (German Centre for Cardiovascular Research), partner site Berlin, Germany, 4Experimental and Clinical Research Center, Charite Medical Faculty and the Max Delbrueck Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

Hypertrophic cardiomyopathy (HCM) is the most frequent inherited monogenic heart disease and could lead to heart failure or even sudden cardiac death. Effective relaxation time T2* is related to different physiological parameters. Dynamic CINE mapping of T2* covering the entire cardiac cycle facilitates distinction of healthy and pathologic myocardial tissue. Here we propose, implement, evaluate and apply an effective approach of retrospective cardiac gating that affords for the first time CINE T2*-mapping in mice at 9.4T and provides the technological basis for translational research into a deeper understanding of the mechanisms underlying hypertrophic cardiomyopathy.

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