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Abstract #2080

Identifying early stages of doxorubicin-induced cardiotoxicity in rat model using 7.0 tesla cardiac magnetic resonanc

Shiyu Wang1 and Fabao Gao1
1Department of Radiology, West China Hospital / West China School of Medicine, Chengdu, China

the aim of this study is to identify early stages of doxorubicin (DOX)-induced cardiotoxicity in rat model using 7.0 tesla cardiac magnetic resonance (CMR) combining creatine kinase isoenzymes (CKMB).Comparison of Ejection fraction (EF), Global radial (GRS), circumferential (GCS) and longitudinal strain (GLS) parameters of LV and CKMB between experimental groups and controls at 4,6, 8, 10 weeks.CKMB can detect DOX-induced cardiotoxicity at the earliest time. Decreased GLS during treatment identifies impaired LV mechanic as an early marker of DOX-induced cardiotoxicity, in the absence of EF. CKMB and CMR-TT are an effective method to evaluate DOX-induced cardiotoxicity at early stage.

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