Abstract #2101

Assessment of myocardial fractional blood volume using Fe-MRI and 3-compartment model of capillary level water exchange in patients with CKD

Douglas Black¹, Sokratis Stoumpos¹, Michael Jerosch-Herold², Neil Chatterjee³, Peter Gatehouse⁴, Geeshath Jayasekera¹, Timothy Carroll⁵, David Kingsmore¹, Colin Berry¹, Patrick Mark¹, Giles Roditi¹, and Aleksandra Radjenovic¹

¹University of Glasgow, Glasgow, United Kingdom, ²Harvard Medical School, Boston, MA, United States, ³University of Pennsylvania, Philadelphia, PA, United States, ⁴Imperial College, London, United Kingdom, ⁵University of Chicago, Chicago, IL, United States

Estimates of myocardial fractional blood volume (FBV), capillary level vascular-interstitial water exchange rate and permeability surface area product were obtained in a cohort of chronic kidney disease (CKD) patients and a control set of healthy volunteers using iron-enhanced MRI (Fe-MRI). FBV was elevated in females, in both CKD patients and control subjects. Fe-MRI also demonstrated reduced permeability surface area product in CKD patients compared to healthy controls, and may provide unique insights into microvascular pathophysiology, particularly in patients with contraindications to gadolinium-based contrast agents.

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