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Abstract #2101

Assessment of myocardial fractional blood volume using Fe-MRI and 3-compartment model of capillary level water exchange in patients with CKD

Douglas Black1, Sokratis Stoumpos1, Michael Jerosch-Herold2, Neil Chatterjee3, Peter Gatehouse4, Geeshath Jayasekera1, Timothy Carroll5, David Kingsmore1, Colin Berry1, Patrick Mark1, Giles Roditi1, and Aleksandra Radjenovic1
1University of Glasgow, Glasgow, United Kingdom, 2Harvard Medical School, Boston, MA, United States, 3University of Pennsylvania, Philadelphia, PA, United States, 4Imperial College, London, United Kingdom, 5University of Chicago, Chicago, IL, United States

Estimates of myocardial fractional blood volume (FBV), capillary level vascular-interstitial water exchange rate and permeability surface area product were obtained in a cohort of chronic kidney disease (CKD) patients and a control set of healthy volunteers using iron-enhanced MRI (Fe-MRI). FBV was elevated in females, in both CKD patients and control subjects. Fe-MRI also demonstrated reduced permeability surface area product in CKD patients compared to healthy controls, and may provide unique insights into microvascular pathophysiology, particularly in patients with contraindications to gadolinium-based contrast agents.

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