Estimates of myocardial fractional blood volume (FBV), capillary level vascular-interstitial water exchange rate and permeability surface area product were obtained in a cohort of chronic kidney disease (CKD) patients and a control set of healthy volunteers using iron-enhanced MRI (Fe-MRI). FBV was elevated in females, in both CKD patients and control subjects. Fe-MRI also demonstrated reduced permeability surface area product in CKD patients compared to healthy controls, and may provide unique insights into microvascular pathophysiology, particularly in patients with contraindications to gadolinium-based contrast agents.
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