The purpose of this study was threefold. First, we validated whether TKE reflects the condition of HOCM and HNCM by comparing them with volunteers. Second, we clarified the factors that increase TKE in HCM. Third, we revealed LV mass which is associated with cardiac load, resulting in a poor outcome. TKE in HOCM was significantly higher than HNCM or volunteers. Maximum velocity, maximum short of the valve orifice, SAM, and LV mass were correlated to TKE. TKE allows to noninvasively depict the flow characteristics and may provide insights into the pathophysiology associated with flow dynamics in HCM.