Abstract #2120

Higher plaque burden of middle cerebral artery is associated with recurrent ischemic stroke: a quantitative study by high-resolution MRI

Yuting Wang¹, Yuncai Ran², Ming Zhu³, Xiao Wu⁴, Ajay Malhotra⁴, Xiaowen Lei², Feifei Zhang², Xiao Wang², Shanshan Xie², Jian Zhou², Jinxia Zhu⁵, Jingliang Cheng², and Chengcheng Zhu⁶

¹Department of Radiology, Sichuan Provincial People's Hospital, Chengdu, China, ²Department of Magnetic Resonance, The first Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ³4. Interventional department, The first Affiliated Hospital of Zhengzhou University, Zhengzhou, China, ⁴Yale School of Medicine and Yale University, New Haven, CT, United States, ⁵MR Collaboration, Siemens Healthcare Ltd., Beijing, China, ⁶3. Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States

Middle cerebral artery plaque burden on high-resolution MR was significantly higher in recurrent stroke group than in the first-onset acute stroke and chronic stroke groups (p=0.002). Patients with acute stroke had higher enhancement ratio than patients with chronic stroke (p=0.014). After adjustment of clinical demographic factors, plaque burden was the only independent imaging feature associated with recurrent stroke (odds ratio=2.26, per 10% increase, 95% CI, 1.03-4.96, p=0.042). In conclusion, higher plaque burden of MCA on MR is independently associated with recurrent ischemic stroke. MR vessel wall imaging may provide unique information for risk stratification of stroke patients.

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