Abstract #2121

Effects of calcification on blood-flow pulsatility variation along the internal carotid artery in small vessel disease patients, a 7T MRI study

Rick J van Tuijl¹, Ynte M Ruigrok², Irene C van der Schaaf¹, Gabriël J. E. Rinkel², Birgitta K Velthuis¹, and Jaco J.M. Zwanenburg¹

¹Radiology, UMC Utrecht, Utrecht, Netherlands, ²Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, UMC Utrecht, Utrecht, Netherlands

The influence of intracranial internal carotid artery calcification (iICAC) over the whole internal carotid artery (ICA) trajectory was studied using 4D phase-contrast flow measurements (17 patients with cerebral small vessel disease (CSVD) and 17 healthy controls; 7T MRI). CT images of CSVD patients were used to calculate the iICAC from C3-C7 segments. Results showed a positive correlation between the presence and volume of iICAC with vPI in the CSVD group. iICAC contributes to an increase in vPI over the ICA from the extracranial C1 segment to the C7 segment just proximal to the circle of Willis compared to HC.

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