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Abstract #2126

Black-blood 3D DCE-MRI of the aortic wall with AIF-free pharmacokinetic modeling: feasibility in abdominal aortic aneurysm patients

Jasper Schoormans1, Claudia Calcagno2, Reza Indrakusuma3, Hamid Jalalzadeh3, Ron Balm3, Stefan Smorenburg4, Gustav J Strijkers1, Aart J Nederveen5, and Bram F Coolen1
1Department of Biomedical Engineering and Physics, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands, 2The BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3Department of Surgery, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands, 4Department of Vascular Surgery, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands, 5Department of Radiology and Nuclear Medicine, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands

We introduced 3D black-blood DCE MRI in combination with AIF-free modeling to facilitate the measurement of pharmacokinetic parameters in the aorta vessel wall of patients with an abdominal aortic aneurysm. Our method enables 3D assessment of microvascularization and permeability which could assist a clinical risk assessment of this condition.

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