Abstract #2128

Chemical Exchange Saturation Transfer Imaging for Atherosclerotic Plaques

Yuki Kanazawa¹, Masafumi Harada¹, Tosiaki Miyati², Takashi Abe¹, Mitsuharu Miyoshi³, Yuki Matsumoto¹, Hiroaki Hayashi², Yasuhisa Kanematsu⁴, and Yasushi Takagi⁴

¹Tokushima University, Tokushima, Japan, ²Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan, ³Global MR Applications and Workflow, GE Healthcare Japan, Hino, Japan, ⁴Department of Neurosurgery, Tokushima University, Tokushima, Japan

To assess an activity within an atherosclerotic plaque, chemical exchange saturation transfer (CEST) imaging was demonstrated with the multi-pool model Bloch equation. This study was performed with eleven patients with carotid stenosis, was evaluated with each estimated parameters; bulk water, magnetization transfer, amide proton transfer (APT), and nuclear Overhauser effect (NOE). There was no significant difference between mean APT and NOE at 3.5 ppm. This result indicates that CEST plaque imaging should be evaluated with distinguishing APT and NOE. Multi-parametric analysis of CEST imaging may obtain detailed information for component as well as metabolite substances within an atherosclerotic plaque.

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