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Abstract #2128

Chemical Exchange Saturation Transfer Imaging for Atherosclerotic Plaques

Yuki Kanazawa1, Masafumi Harada1, Tosiaki Miyati2, Takashi Abe1, Mitsuharu Miyoshi3, Yuki Matsumoto1, Hiroaki Hayashi2, Yasuhisa Kanematsu4, and Yasushi Takagi4
1Tokushima University, Tokushima, Japan, 2Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan, 3Global MR Applications and Workflow, GE Healthcare Japan, Hino, Japan, 4Department of Neurosurgery, Tokushima University, Tokushima, Japan

To assess an activity within an atherosclerotic plaque, chemical exchange saturation transfer (CEST) imaging was demonstrated with the multi-pool model Bloch equation. This study was performed with eleven patients with carotid stenosis, was evaluated with each estimated parameters; bulk water, magnetization transfer, amide proton transfer (APT), and nuclear Overhauser effect (NOE). There was no significant difference between mean APT and NOE at 3.5 ppm. This result indicates that CEST plaque imaging should be evaluated with distinguishing APT and NOE. Multi-parametric analysis of CEST imaging may obtain detailed information for component as well as metabolite substances within an atherosclerotic plaque.

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