Abstract #2130

4-minute 3D Whole Brain 0.6mm Isotropic T1 Weighted Intracranial Vessel Wall Imaging

Zechen Zhou¹, Zhensen Chen², Jie Sun², Niranjan Balu², Baocheng Chu², Peter Börnert³, Thomas S Hatsukami², and Chun Yuan²

¹Philips Research North America, Cambridge, MA, United States, ²Department of Radiology, University of Washington, Seattle, WA, United States, ³Philips Research Hamburg, Hamburg, Germany

Three-dimensional (3D) T1 weighted (T1w) turbo spin echo (TSE) sequence has demonstrated its value for intracranial vessel wall imaging (IVWI), but its long scan time has hampered wider clinical translation. In this study, a 4-minute 3D T1w TSE sequence was optimized and combined with wave encoded parallel imaging and compressed sensing (PI-CS) reconstruction for whole brain isotropic 0.6mm IVWI. This approach improved the image quality and robustness of IVWI in comparison to the Cartesian encoded PI-CS approach in healthy subjects. It demonstrated promising potential for further clinical evaluation.

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