Abstract #2131

Hypertension is Associated with the Diffuseness of Intracranial Atherosclerotic Disease: a Cross-sectional MR Vessel Wall Imaging Study

Jiayu Xiao¹, Jae Song², Fang Wu³, Tao Jiang⁴, Shlee Song¹, Konrad Schlick¹, Debiao Li^1,5, Qi Yang³, and Zhaoyang Fan^1,5

¹Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Hospital of the University of Pennsylvania, Philadelphia, PA, United States, ³Beijing Xuanwu Hospital, Beijing, China, ⁴Beijing Chaoyang Hospital, Beijing, China, ⁵University of California, Los Angeles, Los Angeles, CA, United States

Hypertension is associated with intracranial atherosclerosis and cerebrovascular events. However, the correlation between hypertension and atherosclerosis disease burden (the number, distribution and incidence of vulnerable features of intracranial atherosclerotic plaques) remains unclear. In this study, plaques in the large intracranial arteries of anterior circulation were analyzed in 62 ischemic stroke patients. We found that a diagnosis of hypertension was significantly associated with total number of intracranial plaques after accounting for conventional cardiovascular risk factors. This suggests that hypertension is an important mechanistic factor for diffuse intracranial atherosclerosis.

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