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Abstract #2163

Mechanical properties from CMR parameters in childhood acute lymphoblastic leukemia survivors.

Delphine Perie1, Egidie Uwase1, Tanguy Artz1, Marianna Gamba1, and Daniel Curnier2
1Mechanical Engineering, Polytechnique Montreal, Montreal, QC, Canada, 2Kinesiology, University of Montreal, Montreal, QC, Canada

Swine myocardium mechanical properties were found related to a combination of CMR relaxations times, magnetization transfer and diffusion parameters. Thus we assessed the relationships between mechanical properties and CMR parameters in childhood acute lymphoblastic leukemia survivors. The results showed that the pressure at diastasis, contractility and stiffness properties of the left ventricle can be partially predicted from the relaxation times T1 and T2 and the partition coefficient, reflecting cardiac health in childhood acute lymphoblastic leukemia. This indirect estimation of the mechanical behavior of the myocardium from multiparametric MRI could solve the challenging early cardiac sequelae detection.

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