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Abstract #2164

Preventive fraction of long-term cardiac function with cardiorespiratory fitness and physical activity in childhood leukemia survivors.

Delphine Perie1, Maxime Caru2, Marianna Gamba1, Louise Leleu1, and Daniel Curnier2
1Mechanical Engineering, Polytechnique Montreal, Montreal, QC, Canada, 2Kinesiology, University of Montreal, Montreal, QC, Canada

In childhood leukemia survivors, doxorubicin leads to dose-dependent cardiotoxicity, despite early diagnosis with both echocardiography and MRI investigations. Physical activity has the potential to reduce the chronic disease risk, but it is currently unknown whether a good cardiorespiratory fitness or the regular practice of physical activity is enough to induce a preventive action on the cardiac function. This study included 81 ALL survivors and found that a good cardiorespiratory fitness was associated with a better preventive fraction, similarly to a good physical activity level. It would be more than 80% of the survivors who could benefit from these long-term effects.

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