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Abstract #2165

Comparing intradialytic effects of standard vs cooled haemodialysis on cerebral blood flow and cardiac function using MRI 

Eleanor F Cox1, Latha Gullapudi2,3, Charlotte E Buchanan1, Kelly White3, Sebastian Coleman1, Bernard Canaud4, Maarten W Taal2,3, Nicholas M Selby2,3, and Susan T Francis1
1Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, 2Centre for Kidney Research and Innovation, University of Nottingham, Derby, United Kingdom, 3Renal Unit, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, United Kingdom, 4Fresenius Medical Care, Bad Homburg, Germany

12 patients received standard (SHD) and cooled (CHD) haemodialysis in a randomized cross-over study. Participants underwent serial cardiac and brain multiparametric MRI before, during and after dialysis. Cerebral blood flow velocities fell significantly during dialysis (carotid artery -19±2%, p<0.001; basilar artery -16±3%, p=0.004). Cardiac index and stroke volume index fell significantly during dialysis (-29±2% and -32±2%, both p<0.001). After two weeks of CHD, pre-dialysis left ventricle (LV) myocardial T1 and wall mass (WM) were lower compared to SHD (T1: 1266(37)ms vs. 1311±18ms, p=0.02; LV WM: 128±12g vs. 137±12g, p=0.003), indicating reduced myocardial tissue oedema with CHD.

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