Abstract #2165

Comparing intradialytic effects of standard vs cooled haemodialysis on cerebral blood flow and cardiac function using MRI

Eleanor F Cox¹, Latha Gullapudi^2,3, Charlotte E Buchanan¹, Kelly White³, Sebastian Coleman¹, Bernard Canaud⁴, Maarten W Taal^2,3, Nicholas M Selby^2,3, and Susan T Francis¹

¹Sir Peter Mansfield Imaging Centre, University of Nottingham, Nottingham, United Kingdom, ²Centre for Kidney Research and Innovation, University of Nottingham, Derby, United Kingdom, ³Renal Unit, University Hospitals of Derby and Burton NHS Foundation Trust, Derby, United Kingdom, ⁴Fresenius Medical Care, Bad Homburg, Germany

12 patients received standard (SHD) and cooled (CHD) haemodialysis in a randomized cross-over study. Participants underwent serial cardiac and brain multiparametric MRI before, during and after dialysis. Cerebral blood flow velocities fell significantly during dialysis (carotid artery -19±2%, p<0.001; basilar artery -16±3%, p=0.004). Cardiac index and stroke volume index fell significantly during dialysis (-29±2% and -32±2%, both p<0.001). After two weeks of CHD, pre-dialysis left ventricle (LV) myocardial T1 and wall mass (WM) were lower compared to SHD (T1: 1266(37)ms vs. 1311±18ms, p=0.02; LV WM: 128±12g vs. 137±12g, p=0.003), indicating reduced myocardial tissue oedema with CHD.

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