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Abstract #2166

CMR Feature tracking: reproducibility in small animals

Hao Li1,2, Steffen Just3, Qinghua Lu2, and Volker Rasche1,3
1Core Facility Small Animal Imaging, Ulm University, ULM, Germany, 2Department of Cardiology, The Second Hospital of Shandong University, Jinan, China, 3Department of Internal Medicine II, Ulm University Medical Center, Ulm, Germany

Cardiac magnetic resonance imaging feature tracking (CMR-FT) is a novel non-invasive imaging technique and has been validated in clinical applications. However, there are only limited studies in small animal research. We performed biventricular strain assessment using CMR-FT in nexiline knock-out mice at rest and dobutamine stress to evaluate its feasibility and intra-observer reproducibility in preclinic research. Excellent intra-observer reproducibility could be observed for rest and stress left ventricular (LV) strain in general and right ventricular (RV) circumferential strain derived from short-axis views. An only fair reproducibility was observed for RV longitudinal strain under stress conditions derived from long-axis views.

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