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Abstract #2180

Left Ventricular Twist and Circumferential Strain from MRI Tagging Assess Early Cardiovascular Disease in Duchenne Muscular Dystrophy

Patrick Magrath1,2, Nyasha Maforo2,3, Mike Loecher4, Grace Kim5, Holden H. Wu 1,2,3, Ashley Prosper2, Pierangelo Renella2, Nancy Halnon6, and Daniel B. Ennis 4
1Bioengineering, University of California, Los Angeles, CA, United States, 2Radiology, University of California, Los Angeles, CA, United States, 3Physics and Biology in Medicine IDP, University of California, Los Angeles, CA, United States, 4Radiology, Stanford University, Stanford, CA, United States, 5Biostatistics, University of California, Los Angeles, CA, United States, 6Pediatrics, University of California, Los Angeles, CA, United States

Duchenne Muscular Dystrophy is a common fatal inherited genetic disorder impacting 1:3800 male births, and cardiac failure is the primary source of mortality in this cohort. Decreases in LVEF measured by CINE and fibrosis measured by LGE are late and highly variable outcomes. Herein we demonstrate that peak systolic circumferential strain (Ecc) and Twist measured by MR Tagging provide evidence of earlier changes in cardiac function in a substantial DMD cohort, holding promising applications for patient treatment and the evaluation of novel therapeutics.

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