Abstract #2180

Left Ventricular Twist and Circumferential Strain from MRI Tagging Assess Early Cardiovascular Disease in Duchenne Muscular Dystrophy

Patrick Magrath^1,2, Nyasha Maforo^2,3, Mike Loecher⁴, Grace Kim⁵, Holden H. Wu ^1,2,3, Ashley Prosper², Pierangelo Renella², Nancy Halnon⁶, and Daniel B. Ennis ⁴

¹Bioengineering, University of California, Los Angeles, CA, United States, ²Radiology, University of California, Los Angeles, CA, United States, ³Physics and Biology in Medicine IDP, University of California, Los Angeles, CA, United States, ⁴Radiology, Stanford University, Stanford, CA, United States, ⁵Biostatistics, University of California, Los Angeles, CA, United States, ⁶Pediatrics, University of California, Los Angeles, CA, United States

Duchenne Muscular Dystrophy is a common fatal inherited genetic disorder impacting 1:3800 male births, and cardiac failure is the primary source of mortality in this cohort. Decreases in LVEF measured by CINE and fibrosis measured by LGE are late and highly variable outcomes. Herein we demonstrate that peak systolic circumferential strain (E_cc) and Twist measured by MR Tagging provide evidence of earlier changes in cardiac function in a substantial DMD cohort, holding promising applications for patient treatment and the evaluation of novel therapeutics.

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