Abstract #2221

Carotid Arterial Wall MRI Of ApoE-/- Mouse at 7T using 3D DANTE-Prepared Variable-Flip-Angle Rapid Acquisition with Relaxation Enhancement

Yuanbo Yang¹, Zhonghao Li², Yihao Guo¹, Yingjie Mei³, Ming Zhao², Guoxi Xie⁴, and Yanqiu Feng¹

¹Guangdong Provincial Key Laboratory of Medical Image Processing & Key Laboratory of Mental Health of the Ministry of Education, School of Biomedical Engineering, Southern Medical University, Guangzhou, China, ²Department of Pathophysiology, Key Lab for Shock and Microcirculation Research of Guangdong, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China, Guangzhou, China, ³philips healthcare, Guangzhou, China, ⁴Department of Biomedical Engineering, School of Basic Sciences, Guangzhou Medical University, Guangzhou, China

Carotid atherosclerosis is a degenerative disease of the arterial wall, which can result in predisposition to cerebral thrombo-embolic stroke1. The combination of DANTE and VF-RARE (DANTE-VF-RARE) can suppress flow signal effectively. It was used for vessel wall imaging of human in the previous studies4. However, the feasibility of DANTE-VF-RARE sequence remains unclear for imaging of carotid for apoE-/- mouse. This work aims to develop 3D DANTE-VF-RARE on 7Tesla (T) and investigate its feasibility for vessel wall imaging of apoE-/- mouse.

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