Abstract #2222

Longitudinal assessment of global longitudinal strain and hemodynamic forces in the diabetic mouse heart

Mariah RR Daal¹, Bram F Coolen¹, Dorita THPM Dekkers¹, David Hauteman², Rob CI Wüst³, and Gustav J Strijkers¹

¹Department of Biomedical Engineering, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, Netherlands, ²Medis medical imaging systems B.V., Leiden, Netherlands, ³Faculty of Behavioural and Movement Sciences, Vrije Universiteit, Amsterdam, Netherlands

The current classification of heart failure based on diastolic and systolic dysfunction limits the understanding of the time course of heart failure with preserved left ventricular ejection fraction (HFpEF), and new parameters are warranted to assess cardiac function. Here, we assessed global longitudinal strain (GLS), as well as hemodynamic forces (HDF) in a mouse model of diabetes (db/db) at two time points, with the aim to study the prognostic value of these new parameters for cardiac dysfunction.

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