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Abstract #2239

ATP Degradation Rates are altered in the Diabetic Myocardium: A 31P Saturation Transfer Study (with Dual-band, quasi-Adiabatic Optimal Control)

Jack JJJ Miller1,2,3, Matthew Kerr2, Ladislav Valkovic3,4, Kerstin Timm2, Justin Lau2,3, Paul A. Bottomley5, Lisa Heather2, and Damian Tyler3
1Department of Physics, University of Oxford, Oxford, United Kingdom, 2Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, 3OCMR, Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, 4Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, 5Radiology and Radiological Science, Johns Hopkins, Baltimore, MD, United States

Saturation Transfer 31P MRS enables the quantification of the rate of ATP synthesis and degradation. In this work, we use quasi-adiabatic optimal-control designed single-band (PCr) and dual-band (Gamma ATP + Pi) saturation schemes to separately estimate $$$k_f$$$ and $$$k_r$$$ in the control and diabetic perfused rat heart at 12T. This scheme is rapid, B1 insensitive, and suitable for use at ultrahigh field. We demonstrate profound metabolic alterations in the diabetic myocardium, with a reduction in $$$k_r$$$ and ATP concentration.

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