Abstract #2239

ATP Degradation Rates are altered in the Diabetic Myocardium: A 31P Saturation Transfer Study (with Dual-band, quasi-Adiabatic Optimal Control)

Jack JJJ Miller^1,2,3, Matthew Kerr², Ladislav Valkovic^3,4, Kerstin Timm², Justin Lau^2,3, Paul A. Bottomley⁵, Lisa Heather², and Damian Tyler³

¹Department of Physics, University of Oxford, Oxford, United Kingdom, ²Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom, ³OCMR, Cardiovascular Medicine, University of Oxford, Oxford, United Kingdom, ⁴Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia, ⁵Radiology and Radiological Science, Johns Hopkins, Baltimore, MD, United States

Saturation Transfer 31P MRS enables the quantification of the rate of ATP synthesis and degradation. In this work, we use quasi-adiabatic optimal-control designed single-band (PCr) and dual-band (Gamma ATP + Pi) saturation schemes to separately estimate $$$k_f$$$ and $$$k_r$$$ in the control and diabetic perfused rat heart at 12T. This scheme is rapid, B1 insensitive, and suitable for use at ultrahigh field. We demonstrate profound metabolic alterations in the diabetic myocardium, with a reduction in $$$k_r$$$ and ATP concentration.

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