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Abstract #2240

RF Coil and Gradient Shim Considerations for Hyperpolarized 13C Imaging of the Human Myocardium

Galen Durant Reed1, JaeMo Park2, Junjie Ma2, Crystal Harrison2, Rolf Schulte3, Albert Chen 4, Salvador Pena2, Jeannie Baxter2, Kelley Derner2, Maida Tai2, Dean Sherry2, Vlad G Zaha2, and Craig R Malloy2
1GE Healthcare, Dallas, TX, United States, 2University of Texas Southwestern Medical Center, Dallas, TX, United States, 3GE Healthcare, Munich, Germany, 4GE Healthcare, Toronto, ON, Canada

Initial human hyperpolarized 13C cardiac imaging experiments utilized a frequency-selective, single-shot spiral pulse sequence for encoding, and a rigid 8 channel receiver array paired with a Helmholtz clamshell transmitter. In phantom studies, we evaluate this RF hardware along with flexible transmit / receiver designs and test these in healthy volunteers. Furthermore, as pointed out previously, the detected circumferential distribution of [13C]bicarbonate around the myocardium is often non-uniform in pigs, thus confounding the translation of this technique for regional metabolism evaluation. We observed this artifact in human volunteers and explore its possible sources.

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