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Abstract #2244

Magnetic Nanoparticle Sensor for Longitudinal Biomarker Monitoring

Richard Joshua Murdock1,2 and Michael Cima2,3
1Health Sciences & Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, 2Koch Institute For Integrative Cancer Research, Cambridge, MA, United States, 3Materials Science & Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States

Continuous biochemical monitoring remains a critical challenge in the biosensing community as longevity, biocompatibility, and signal transduction limit multi-month implantation. We propose a novel design and evaluation of the sensing capability of a magnetic nanoparticle dosimeter assay for in vivo implementation, readable by magnetic relaxation. This local diagnostic device offers continuous sentinel evaluation and longitudinal tracking of critical biomarkers found to correlate with cardiovascular disease states. The current design exhibits an order of magnitude improvement in performance compared to prior studies, translating into a predicted 29 week lifetime.

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