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Abstract #2269

4D flow MRI vs. Doppler Echocardiography: Data Integration Framework for Direct Comparison of Intra-cardiac Flow Dynamics

Jeesoo Lee1,2, Nadia El Hangouche2, Alex J Barker3, James D Thomas2, and Michael Markl1,4
1Radiology, Northwestern University, Chicago, IL, United States, 2Cardiology, Northwestern Memorial Hospital, Chicago, IL, United States, 3Radiology, University of Colorado Denver, Denver, CO, United States, 4Biomedical Engineering, Northwestern University, Chicago, IL, United States

We developed a framework to integrate 4D flow MRI with color Doppler echocardiography (CDE) for direct localized inter-modal velocity comparison. The framework combines CDE and 4D flow MRI data by using cine-MRI and a two-step image registration; 1) registration of CDE to cine-MRI and 2) registration of cine-MRI to 4D flow MRI. As a result, a voxel-wise inter-modal velocity difference map overlaid to a tissue image was constructed. Six healthy subjects with a same-day CDE and 4D flow MRI were utilized and a strong correlation with moderate agreement was found in the LVOT.

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