Abstract #2280

Impact of Vessel Wall Characteristics on Quantitative 4D-Flow Dynamics in Compliant 3D-Printed Thoracic Aorta Models.

Judith Zimmermann^1,2,3, Kathrin Bäumler¹, Michael Loecher^1,3, Alison Marsden^4,5, and Daniel Ennis^1,3,5

¹Radiology, Stanford University, Stanford, CA, United States, ²Computer Science, Technical University of Munich, Munich, Germany, ³Radiology, Veterans Administration Health Care System, Palo Alto, CA, United States, ⁴Pediatrics, Stanford University, Stanford, CA, United States, ⁵Cardiovascular Institute, Stanford, CA, United States

A detailed understanding of flow dynamics in the aorta is of clinical interest and enabled by 4D-flow MRI. This work presents an in vitro flow circuit that embeds a subject-specific 3D-printed compliant aorta model to demonstrate feasibility while also exploring the impact of vessel wall characteristics (thickness, stiffness) and heart rate on quantitative flow dynamics. The experimental setup will be a valuable tool for assessing 4D flow MRI sampling requirements, generating high-quality ground truth data for CFD and FSI validation, as well as studying flow dynamics in different vascular pathologies.

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