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Abstract #2280

Impact of Vessel Wall Characteristics on Quantitative 4D-Flow Dynamics in Compliant 3D-Printed Thoracic Aorta Models.

Judith Zimmermann1,2,3, Kathrin Bäumler1, Michael Loecher1,3, Alison Marsden4,5, and Daniel Ennis1,3,5
1Radiology, Stanford University, Stanford, CA, United States, 2Computer Science, Technical University of Munich, Munich, Germany, 3Radiology, Veterans Administration Health Care System, Palo Alto, CA, United States, 4Pediatrics, Stanford University, Stanford, CA, United States, 5Cardiovascular Institute, Stanford, CA, United States

A detailed understanding of flow dynamics in the aorta is of clinical interest and enabled by 4D-flow MRI. This work presents an in vitro flow circuit that embeds a subject-specific 3D-printed compliant aorta model to demonstrate feasibility while also exploring the impact of vessel wall characteristics (thickness, stiffness) and heart rate on quantitative flow dynamics. The experimental setup will be a valuable tool for assessing 4D flow MRI sampling requirements, generating high-quality ground truth data for CFD and FSI validation, as well as studying flow dynamics in different vascular pathologies.

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